Royal College of Surgeons in Ireland
Title: Postdoctoral Researcher
Department: Endocrine Oncology Research Group (EORG) within the Dept of Surgery, RCSI
Location: Dept of Surgery, York House, 31A York Street, RCSI, Dublin 2
Reporting to: Professor Leonie Young
Salary: Dependent on level of experience and based on the most current IUA Researcher’s Salary Scales IUA Researcher’s Salary Scales.
The Royal College of Surgeons in Ireland (RCSI) is a private, self-financing, not-for-profit medical and surgical college headquartered in Dublin (Ireland) with global reach through its overseas medical universities and health care centres in the Middle East, the Far East and Africa. Since its foundation in 1784, it has played a leadership role in Irish surgical and medical education. Currently, it operates the largest Medical School in Ireland and provides undergraduate education in Physiotherapy, Pharmacy, and Nursing. In addition to Surgery, it also provides postgraduate training and education in Radiology, Dentistry, Nursing & Midwifery, Sports and Exercise Medicine, Healthcare Management and Leadership, and has an Institute of Research.
RCSI recognises that excellence in research is critical to the quality of its educational activities, its credibility, and, overall, to its mission to enhance human health. Recently, RCSI has implemented a new research strategy that will build upon its strength in translational biomedical and clinical research to deliver transformational, high impact changes in health care. Targeting both Irish national and EU funding, along with increased collaboration with industry, is a major part of the RCSI research strategy. Forging increased collaboration between RCSI PIs and industry is of critical importance to achieving success in this area. RCSI is also committed to provide its researchers with the supports and developmental opportunities to enable them to continuously grow and support their overall career development.
Overall purpose of this position
We are seeking to recruit a talented, enthusiastic and highly motivated Postdoctoral Researcher to join the Endocrine Oncology Research Group, based at the Royal College of Surgeons in Ireland. Our lab focuses on elucidating the role of nuclear steroid receptors and pro-metastatic pathways in breast cancer pathogenesis. The successful candidate will deliver research as part of the Breast Cancer Now Project Grant focusing on elucidating novel molecular determinants of breast cancer brain metastases. These studies are built on our recent findings (J Natl Cancer Inst. PMID:29961873; Clin Cancer Res PMID:29567811; JAMA Oncol PMID:27926948). The research project will be conducted in a highly collaborative and productive environment. Candidates should have a PhD, a strong training background in cancer biology and a good publication record. Successful candidate will be expected to design experimental plans, lead study execution, analyse experimental data and prepare manuscripts with minimum supervision from senior team leads. The project will use a wide range of molecular biology techniques, transcriptomic/epigenomics methods, CRISPR genome editing, organoid culture and in vivo mouse models. Experience with patient derived samples and strong in vivo background is desired.
Key Responsibilities and Deliverables
- To lead study execution with respect to evaluation and characterisation of novel biological targets in metastatic breast cancer
- To independently plan, execute, analyse, and manage multiple in vitro/in vivo/ex vivo experiments simultaneously
- To maintain accurate, detailed records of experimental data and protocols
- To create visually impactful representations of data for publications and presentations
- To work in a team environment and, as needed, train new personnel and mentor postgraduate students as required
- Contribute to the preparation of high-impact peer review scientific publications and to disseminate research findings at national and international meetings
- A PhD in relevant area such as breast cancer oncology, immunology, molecular biology etc. with research in a relevant scientific area
- Minimum second class (2.1) honours degree or equivalent in a relevant subject
Knowledge & Experience– (Essential):
- Experience in routine molecular biology techniques such as western blot, PCR, genome editing and tissue culture, immunohistochemistry and confocal microscopy.
- Hands-on experience performing in vivo studies, preferably with small molecule drug candidates using multiple dose routes (IV, SC, IP), tissue sample collection, and evaluating experimental endpoints.
Knowledge & Experience– (Desireable):
- Previous experience in mouse surgery and in vivo
- Experience in translation of novel therapeutics.
- Bioinformatic and statistical analysis skills.
- Current Laboratory Animal Science and Training (LAST Ireland) certificate or equivalent.
Skills & Competencies:
- Communication Skills: Proven ability to communicate complex ideas
- Project Management Skills: Ability to ensure that project plans are communicated and that all timelines are met
- Self-starter with the ability to work as part of a team: Ability to operate effectively as part of a team – is cordial, tolerant and willing to help others, is co-operative and patient; shares work and information; establishes rapport, can influence and develop effective networks
- T. skills: Knowledge of MS Office suite.
- Conscientious: Have a pro-active approach to work, anticipating and resolving problems in advance; have keen attention to detail - from anticipating and addressing issues in advance to understanding requests and delivering quality work with minimal errors.
- Flexibility: Can operate flexibly within a busy environment; can shift focus when required.
- Customer Focus: Have strong customer service skills. Be able to communicate with a high level of initiative, tact, diplomacy and confidentiality.
- Motivated: Display a ‘can-do’ attitude, be committed to RCSI ORI and its development; demonstrate enthusiasm and passion for the role.
Please apply online no later than 5pm on the closing date with your CV and Covering Letter.
Informal Enquiries can be directed to Dr Damir Vareslija: firstname.lastname@example.org